Metabolic Health
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56 articles in Metabolic Health
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56 articles in Metabolic Health
The Continuous Glucose Monitoring Revolution: How Real-Time Data Is Transforming Diabetes Care
A Tiny Sensor, A Wealth of Insight Continuous glucose monitoring (CGM) devices are transforming diabetes care by providing patients and clinicians access to a wealth of real-time glucose data. At the core of this technology is a tiny sensor, thinner than a human hair, which is inserted just under the skin to measure glucose levels…
The Critical Link Between Sleep and Alzheimer's Disease Risk
Evidence Mounts that Insufficient Sleep Contributes to Cognitive Decline Emerging research over the past decade has uncovered compelling evidence for a connection between poor sleep quality and quantity and increased risk for Alzheimer's disease. Scientists have discovered links at the molecular level related to the accumulation of beta amyloid plaques and tau tangles, the two…
Optimizing Glucose Control and Insulin Levels for Better Health
The Growing Burden of Type 1 Diabetes Type 1 diabetes is an autoimmune disease where the immune system attacks and destroys the insulin-producing beta cells in the pancreas. This results in a lack of insulin production and an inability to control blood glucose levels. The incidence of type 1 diabetes has doubled since the 1960s,…
Unraveling the Genetic and Physiological Basis of Obesity: The Discovery of Leptin
The Early History of Obesity Research In the 1960s, Dr. Douglas Coleman at the Jackson Laboratory began studying single-gene mouse mutations like ob/ob and db/db that caused severe early onset obesity. Through elegant parabiosis experiments joining the circulations of these mutant mice to normal mice, Dr. Coleman provided some of the earliest evidence that ob/ob…
Demystifying Lipoproteins: A Closer Look at These Crucial Particles
The Discovery of Lipoproteins In the 1940s, scientist John Gofman made a pivotal discovery – that fats and cholesterol do not travel solo through the bloodstream. Instead, they ride along inside spherical particles called lipoproteins. Gofman uncovered lipoproteins' existence using an ultracentrifuge, which spins blood plasma at high speeds to separate its components…
Uncovering the Hidden Causes of Small Intestinal Bacterial Overgrowth
Recognizing the Signs and Symptoms of this Common Condition Small intestinal bacterial overgrowth (SIBO) has become increasingly prevalent in recent years. Although testing methods have improved, allowing for better recognition, experts believe lifestyle factors and an aging population have also contributed to rising rates. Patients with SIBO may experience digestive symptoms like bloating, abdominal pain,…
Unlocking the Secrets of Longevity: How mTOR Inhibition May Extend Lifespan
Introducing mTOR: A Cellular Master Regulator At the center of some of the cell’s most vital activities sits a pivotal protein complex known as the mechanistic target of rapamycin, or mTOR. This critical signaling hub serves as a master integrator of cues from nutrients, growth factors, oxygen, and more to dictate major cell functions. Given…
Targeting Cancer's Sweet Tooth: The Links Between Insulin, Sugar, and Cancer Growth
The Discovery of PI3 Kinase Signaling in Both Insulin and Oncogenes In the 1980s, Dr. Lou Cantley made a breakthrough discovery regarding an enzyme called PI3 kinase. He realized it was a key player in insulin signaling that helped cells take up glucose. But he also found that PI3 kinase activity was increased by oncogenes…